HIT Assays

HIT Assays and Controls products are available worldwide

Enzyme immuno-assay designed for measuring globally all heparin-dependent antibodies, whether the isotype is: IgG, IgM and IgA, in human plasma or serum, or in any biological fluid where these antibodies must be measured. This assay is proposed as screening, as an early identification of heparin treated patients presenting a risk to develop HIT or HITT. This assay measures the whole of antibodies. It offers the highest sensitivity as all isotypes are detected. It is the preferred assay when an early detection of heparin dependent antibodies is required for assessing the development risk of HIT/HITT.

Assay characteristics	Kit components	Applications
Total Assay Time:                                                     2h15 Cut-off:                                                            A450 ≥ 0.50 Dynamic Range:                                            A450 up to 3.0 Intra-Assay CV:                                                      4 - 6% Inter-Assay CV:                                                     5 – 8%	12x8 test kit 2x HIA Sample Diluent 3x HIA IgGAM positiveControl 3x Negative control 3x Platelet lysate 3x Anti-IgG (Fcg)- IgM (m)- IgA(a)-HRP IC 1x Conjugate Diluent 1x Wash Solution 1x TMB 1x 0.45M Sulfuric Acid	Assessment of the risk to develop HIT/HITT, in patients treated with heparins (Unfractionated or LMWH): presence of antibodies is a risk indicator for development of HIT/HITT. Clinical suspicion of HIT during heparin therapy.

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