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Aniara Grant

2012 Coagulation Grant Winner


Aniara is happy to announce the winner of the 2012 Aniara grant in the amount of $10,000 - Chad M. Paton, PhD.

Chad M. Paton, PhD
Chad M. Paton, PhD
Asst. Prof. in Nutritional Sciences
Director of the BMNL
Texas Tech University
Lubbock, Texas

Biography

Dr. Paton joined the faculty at Texas Tech University in 2011 after completing his postdoctoral training at the University of Wisconsin-Madison in the department of Biochemistry. While at UW, his work was focused on developing mouse and cell based models of diet induced obesity to study the regulation of lipid metabolism. Prior to that, he was a postdoctoral fellow at the Blood Research Institute in Milwaukee, WI investigating the mechanisms by which fibrin degradation products caused cell death. He completed his PhD at the University of Maryland in College Park (2005) and undergraduate work at Michigan State University (2000).

Abstract

Fibrin fragment-E mediated induction of adipose tissue inflammation.

We suspect that fibrin degradation products may be mediating adipocyte inflammation and subsequent insulin resistance and an early event in the development of glucose intolerance is adipose inflammation. Fibrin deposition is well known to induce local inflammation; however it has yet to be demonstrated to contribute to obesity induced adipose inflammation. Therefore, the purpose of this project is to establish the ability of fibrin degradation product E-fragment (FDP-E) to induce inflammation in macrophages and adipocytes. To test this concept, we will first determine the effect of FDP-E on macrophage inflammation by assessing M1 and M2 phenotypes and cytokine production in the presence of various concentrations of FDP-E. Next, we will evaluate the ability of exogenous FDP-E injected into the adipose tissue of mice to stimulate adipocyte inflammation and induce macrophage activation. This project is intended to define the role of FDP-E on adipose tissue inflammation and will establish fibrinogen, FDP-E, and thrombosis as primary causes of adipose tissue dysfunction with obesity.

 

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Winners

Current

2013 - Luigi Brunetti, PharmD, MPH, BCPS, CGP

Previous

2012 - Dr. Chad M. Paton, PhD
2010 - Leonardo R. Brandao, MD
2009 - Dr. Mirta Schattner Ph.D.
2008 - Dr. Graciela Krikun, Ph.D.
2007 - Dr. Margaret Prechel, Ph.D.
2006 - Dr. A. Valance Washington, Ph.D

Scientific Advisiors

Dr. Dorothy Adcock
Medical Director/Laboratory Director Colorado Coagulation Consultants, Inc, dba Esoterix Coagulation Denver, Colorado

Dr. Kenneth A. Bauer
Professor of Medicine, Harvard Medical School. His hospital positions include Chief, Hematology Section, VA Boston Healthcare System, and Director, Thrombosis Clinical Research, Beth Israel Deaconess Medical Center.

Dr. Charles S. Eby
Associate Director of Educational Programs, Division of Laboratory Medicine at Washington University Saint Louis, Member of Barnes-Jewish Hospital Credentialing and Health Information Management Committees.

Dr. Andreas Hillarp
Position as hospital chemist at the Department of Clinical Chemistry, University Hospital, Malmö, Sweden.

Dr. Mervyn A. Sahud, M.D., A.B.I. M.-Hem.
Medical Director Coagulation Department Quest Diagnostics Nichols Institute

Dr. Sam Schulman
Associate professor in Internal Medicine at Karolinska Institute and since September 2004 also professor in medicine at McMaster University.

Agneta Siegbahn, MD, Ph.D.
Professor in Clinical Coagulation Science Department of Medical Sciences, Clinical Chemistry Akademiska Hospital, Uppsala, Sweden

Jogin R. Wu, Ph.D.
Associate Clinical Professor of Pathology, Duke University Medical Center. Associate Director, Clinical Coagulation Laboratory, Duke University Health System.

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